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run three-sample MR using MR-GRAPPLE

runGRAPPLE.Rd

run three-sample MR using MR-GRAPPLE

Usage

runGRAPPLE(
  selGWAS.file,
  expGWAS.file,
  outGWAS.file,
  pval,
  ldRef,
  clump_r2 = 0.001,
  outPath
)

Arguments

selGWAS.file

dataset with selection GWAS summary statistics

expGWAS.file

dataset with exposure GWAS summary statistics

outGWAS.file

dataset with outcome GWAS summary statistics

pval

threshold of p-value for SNPs selection

ldRef

location of ld reference panel

clump_r2

the r2 used for clumping

outPath

the path for saving figures generated from MR-GRAPPLE